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As is the case with any other medication, there may be some instances where methocarbamol interactions can occur. In such cases, use is not recommended or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with methocarbamol include the following.

  • Anticholinesterase agents

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Methocarbamol and Tizanidine

Tizanidine (Zanaflex) and methocarbamol are both muscle relaxants. Both of these drugs have a sedative effect, so taking them together would likely exacerbate side effects such as sleepiness and poor concentration. 

Methocarbamol and Tylenol

Methocarbamol is a muscle relaxant, and Tylenol (acetaminophen) is a pain reliever. There are no known interactions between these drugs. In some countries, like Canada, the two actually come combined in one medication for muscular pain relief

Methocarbamol and Tramadol

Tramadol (ConZip, Ultram) is a narcotic pain reliever with a sedative effect. It’s not recommended that these two medications be taken together because they both depress the central nervous system. That may lead to respiratory problems and even coma.

Methocarbamol and Aleve

The primary ingredient in Aleve is naproxen, which is a nonsteroidal anti-inflammatory agent (NSAID). There is no known interaction between naproxen and methocarbamol. 

Methocarbamol and Xanax

Xanax (alprazolam) is a benzodiazepine used to treat anxiety disorders. Taking methocarbamol and Xanax together could increase the side effects of either drug, including dizziness, drowsiness, and confusion. 

Methocarbamol and Advil

Advil (ibuprofen) is a nonsteroidal anti-inflammatory agent. There are no known interactions between Advil and methocarbamol. 

Methocarbamol and Lexapro

Lexapro (escitalopram) is an SSRI antidepressant. Taking it with methocarbamol will likely enhance the sedative side effects such as sleepiness, dizziness, and confusion. 


Gabapentin (Neurontin) is an anticonvulsant medication and also used for nerve pain. Taking it with methocarbamol will probably enhance some of their common side effects like sleepiness and confusion. 


Warfarin (Coumadin) is an anticoagulant or blood thinner. There is some evidence that taking methocarbamol with drugs that thin the blood may increase the risk of bleeding.


Diphenhydramine is an antihistamine, and like most, it can make you drowsy. Combining it with methocarbamol may intensify that effect. 


Losartan (Cozaar) is medication to treat high blood pressure. There is no indication of interaction between losartan and methocarbamol. Some high blood pressure medications such as amlodipine or metoprolol can lead to an increase in side effects when taking with methocarbamol, though. 


There is no indication of an interaction between methocarbamol and antibiotics. A prescribing physician should always be made aware of any medication a patient takes, however, when they are prescribing an antibiotic. 


Xarelto (rivaroxaban) is an anticoagulant medication. Methocarbamol can increase the risk of bleeding with taken with anticoagulants. 

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with methocarbamol include:

  • Alcohol

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Methocarbamol and Alcohol

For more information, please visit our page on methocarbamol and alcohol interactions.

Disease & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to Prescriber’s Digital Reference, diseases and medical conditions that are known to interact with methocarbamol negatively include:

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Methocarbamol and Pregnancy

For more information, please visit our page on methocarbamol and pregnancy risks.

Other Interactions

Other potential interactions include the following.

Methocarbamol and Weed

There is no indication of an interaction between methocarbamol and marijuana, or “weed.” Both drugs have a sedative nature, though, so it’s likely that weed will enhance some of the side effects of methocarbamol, such as sleepiness and lack of coordination.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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