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Xanax and grapefruit interactions can occur, so it is important to avoid eating this fruit or drinking its juice while on alprazolam. 

Interactions between Xanax and Grapefruit

Grapefruit interferes with liver enzymes that break down Xanax. As a result, the amount of Xanax in the system can build up to dangerous levels. This buildup can enhance side effects and increase the risk of overdose. 


What medications should not be taken with grapefruit?

Grapefruit can interfere with how the liver metabolizes certain medications such as:

  • Benzos like Xanax (alprazolam)
  • Statins like Lipitor (atorvastatin)
  • Antihistamines like Allegra (fexofenadine)
  • Calcium channel blockers for blood pressure like Adalat (nifedipine)
  • Immunosuppressants like Prograf (tacrolimus)
  • Pain medications like methadone (Diskets, Methadone Intensol, Methadose)
  • Impotence drugs for erectile dysfunction like Viagra (sildenafil)
  • The HIV medication Invirase
  • Antiarrhythmics containing amiodarone (Pacerone, Nexterone)

What can you not take with alprazolam?

You should not take another benzodiazepine like Valium, Ketoconazole (Nizoral), Itraconazole or (Sporanox). You should also avoid grapefruit, foods, grapefruit juice, and foods containing either. 

What supplements interact with Xanax?

Some possible interactions include kava kava, melatonin, dehydroepiandrosterone (DHEA, androstenolone), St. John’s wort (Hypericum perforatum), and valerian. 

Can I take Xanax with valerian root?

Valerian root may enhance the side effects of this drug, so mixing the two is not recommended.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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