A golden retriever puppy scratching fleas behind his ears.

Protecting dogs from fleas, ringworms and the like is critical to their overall health. Because there are a wide range of medications available to prevent and protect against these mites, pet owners can struggle in determining the best option for their dog. Trifexis is among the most common medications for dogs who need flea and mite protection. But is it right for your furry friend?

What is Trifexis?

Trifexis is a chewable medication that can treat and assist with the following in dogs, according to 1-800-PetMeds:

  • Prevention and protection from fleas, parasites, roundworms, hookworms, whipworms and heartworm disease

1-800-PetMeds states Trifexis should only be prescribed to dogs at least eight weeks old and with a weight of at least five pounds. Dogs who will be bred or who are pregnant or nursing should not, in most cases, take Trifexis.

Is Trifexis safe for dogs?

Trifexis is FDA-approved for veterinary medicine. It is, however, advisable to always consult with your pet’s veterinarian before ever starting treatment for them with this drug.


Dosage may differ from one dog to another, and your veterinarian will know what’s best for your pet’s health. It is also important to talk with your pet’s veterinarian about any potential interactions with other medications, health conditions or supplements. Consult your pet’s vet for personalized dosing instructions.

Side Effects

Just like with any other medication, there’s a chance your dog might experience side effects with Trifexis. Such side effects may include but are not limited to:

  • Vomiting
  • Mood changes
  • Diarrhea
  • Cough
  • Increased thirst
  • Barking
  • Appetite change

Please note this list may not be exhaustive. If your dog experiences any side effects, call their vet immediately.

Final Thoughts

Before starting your pet on Trifexis, make sure to go over all of the potential side effects and risks with your pet’s veterinarian. And, continue to follow up both during and after treatment to make sure your pet’s safety and health are in check.

Disclaimer: This article does not constitute professional medical advice, nor can it replace the advice of a licensed professional.

Written by