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Little data exist regarding the human consumption of cyclobenzaprine during and after pregnancy. Animal studies involving rats, mice and rabbits provide information regarding the potential for birth defects and other risks associated with taking cyclobenzaprine during pregnancy or while breastfeeding.

As with any other medication, however, it is critical to consult with your doctor before taking cyclobenzaprine if you are pregnant, think you are pregnant or plan to become pregnant.

The FDA recommends cyclobenzaprine for pregnant and breastfeeding women only when deemed necessary. Animal studies are only used for guidance, and therefore, it is critical for pregnant and/or breastfeeding women to only take cyclobenzaprine if their physician determines it is absolutely necessary.

Can cyclobenzaprine cause birth defects during pregnancy?

The risk of cyclobenzaprine causing birth defects on human babies is unknown.

The FDA reports data from rat, mice and rabbit studies that conclude no impairment on fertility nor fetal harm, even at doses 20 times higher than the human dose. 

Can cyclobenzaprine cause a miscarriage?

The risk of having a miscarriage due to the consumption of cyclobenzaprine during pregnancy is unknown. It is advisable to consult with your doctor before taking a muscle relaxant in order to assess its risk on your pregnancy.

Cyclobenzaprine, Labor and Delivery

There is not enough data available on the safety risks associated with taking cyclobenzaprine during pregnancy and its effect on labor and delivery.

Cyclobenzaprine and Lactation

Cyclobenzaprine’s composition is similar to tricyclic antidepressants, which are known to excrete in human milk. Therefore, doctors should prescribe this medication with caution to nursing mothers.

Cyclobenzaprine and Fertility

Both male and female rats given doses up to ten times the human dose of cyclobenzaprine did not display any adverse effects in their fertility, according to the FDA. Male rats given doses up to 20 times the human dose of cyclobenzaprine still did not demonstrate mutagenic activity.

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