Sildenafil may be used in cisgender women for female sexual arousal disorder (FSAD) as well as for the treatment and management of PAH. Surprisingly, recent research has also examined the potential effects of sildenafil citrate during pregnancy.
For example, one 2005 study published in The Journal of Clinical Endocrinology & Metabolism found that taking sildenafil improved blood vessel function and vasodilation (vessel widening) in pregnant people experiencing intrauterine fetal growth restriction, suggesting a possible benefit of improving uterine blood flow. This study was corroborated by a 2019 meta-analysis published in PLOS One, which found that sildenafil “could be associated with increasing fetal weight at birth in placental insufficiency.”
More research is needed to determine if sildenafil is safe during pregnancy, but many doctors and researchers believe the medication may be safe for pregnancy when indicated and while under medical supervision. Use is currently not recommended.
Sildenafil and Lactation
A small amount of data suggests that sildenafil is not readily absorbed and excreted into the breastmilk. While this suggests the medication may be safe for lactating individuals and their infants, breastfeeding parents should check with their doctors before taking sildenafil.
FAQ
Is sildenafil safe during pregnancy?
Sildenafil is generally thought to be safe during pregnancy, with a low risk of adverse effects reported. Some studies even suggest that pregnant people struggling with intrauterine growth restriction may benefit from taking sildenafil because it may help increase blood flow. There is not enough data present and as a result use is not recommended.
Does sildenafil citrate affect fertility?
It’s not certain if sildenafil affects fertility. Research suggests it’s possible, though. One 2007 study published in Fertility and Sterility suggested that although the medication led to increased sperm speed and motility, it also negatively affected the way sperm interacted with the egg (the study was performed using sperm samples in a laboratory setting). These findings led the authors to conclude that sildenafil may negatively affect fertility. More research would be beneficial to clarify if and how the drug affects fertility, however.
Does Viagra help with pregnancy?
According to some news outlets, sildenafil has been used in select fertility clinics to help individuals undergoing in vitro fertilization (IVF) to become pregnant. It’s believed that the medication may help increase uterine blood flow and therefore thicken the walls of the womb, potentially increasing the chances that a fertilized egg will “take” or implant.
Studies have also shown that sildenafil may help improve blood flow to the uterus in pregnant people experiencing intrauterine growth restriction. Doctors and scientists are still exploring whether this drug can be useful for some pregnant individuals.
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