The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
Body as a Whole:
Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs)
Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia
Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia
Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura
Electrolyte imbalance such as hypercalcemia, hypokalemia, hypomagnesemia, and hyponatremia (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia
Vertigo, paresthesias, dizziness, headache, restlessness
Renal failure, renal dysfunction/insufficiency, interstitial nephritis (see WARNINGS)
Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia
Transient blurred vision, xanthopsia
Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.