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Below are the general guidelines for dosing hydrochlorothiazide. Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking hydrochlorothiazide.

The following information comes from DailyMed, an FDA label information provider.

What if I miss a dose of Hydrochlorothiazide?

According to Mayo Clinic, if you miss a dose of hydrochlorothiazide, take it immediately unless you are closer in time to your next dose. Never double dose.

What if I overdose on Hydrochlorothiazide?

The most commons signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis or digoxin has also been administered, hypokalemia may accentuate cardiac arrhythmias.

In the event of overdosage, symptomatic and supportive measures should be employed. Correct dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. If required, give oxygen or artificial respiration for respiratory impairment. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.

The oral LD50 of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat model.

Dosage and Administration

Therapy should be individualized according to patient response. Use the smallest dosage necessary to achieve the required response.

Adults

For Edema

The usual adult dosage is 25 to 100 mg daily as a single or divided dose. Many patients with edema respond to intermittent therapy, i.e., administration on alternate days or on three to five days each week. With an intermittent schedule, excessive response and the resulting undesirable electrolyte imbalance are less likely to occur.

For Control of Hypertension

The usual initial dose in adults is 12.5 mg to 25 mg daily given as a single dose. The dose may be increased to 50 mg daily, given as a single or two divided doses. Doses above 50 mg are often associated with marked reductions in serum potassium (see also PRECAUTIONS).

Patients usually do not require doses in excess of 50 mg of hydrochlorothiazide daily when used concomitantly with other antihypertensive agents.

Infants and Children

For Diuresis and For Control of Hypertension

The usual pediatric dosage is 0.5 to 1 mg per pound (1 to 2 mg/kg) per day in single or two divided doses, not to exceed 37.5 mg per day in infants up to 2 years of age or 100 mg per day in children 2 to 12 years of age. In infants less than 6 months of age, doses up to 1.5 mg per pound (3 mg/kg) per day in two divided doses may be required. (See PRECAUTIONS, PEDIATRIC USE)

How is Hydrochlorothiazide supplied?

Hydrochlorothiazide Tablets, USP, 25 mg are peach colored, round, uncoated, flat-faced beveled edge, tablets debossed with ‘428’ on one side and scored on the other side are available as follows:

Bottles of 100                NDC 57664-428-88
Bottles of 500                NDC 57664-428-13
Bottles of 1000              NDC 57664-428-18

Hydrochlorothiazide Tablets, USP, 50 mg are peach colored, round, uncoated, flat-faced beveled edge, tablets debossed with ‘429’ on one side and scored on the other side are available as follows:

Bottles of 100                NDC 57664-429-88
Bottles of 500                NDC 57664-429-13
Bottles of 1000              NDC 57664-429-18

Store at 20° to 25°C (68° to 77°F); excursions permitted 15° to 30°C (59° to 86°F) [see USP Controlled Room Temperature].

Protect from light and moisture.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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