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When stopping Rexulti (brexpiprazole), withdrawal symptoms may arise. It is important to ask your doctor for guidance on how to taper off this medication. 

How Long Do Rexulti Withdrawal Symptoms Last?

Rexulti’s withdrawal symptoms appear within the first few days of stopping or substantially reducing drug dosage. They tend to peak within a week from stopping the medication and start to ease after that. Always follow your doctors instructions for stopping a medication. It is recommended to gradually reduce dosages to avoid some withdrawal symptoms.

Withdrawal Symptoms

Some of the symptoms that you may experience when discontinuing antipsychotics are:

  • Vomiting, nausea, and diarrhea
  • Difficulty sleeping, restlessness, anxiety, and agitation
  • Dizziness
  • Runny nose
  • Problems with muscle movement, including involuntary muscle contractions, inability to stay still, and uncontrollable movements


There is limited research on Rexulti’s withdrawal symptoms, but some evidence suggests that up to 40% of the people who stop taking antipsychotics may experience withdrawal symptoms. You may be at greater risk if you have been on the medication for a long time. Seek medical help if you want to stop Rexulti.

Treatment Options

If you are struggling with misusing antipsychotics and coming off medications, seek help at general mental health care providers and providers that specialize in substance use disorders specifically. Specialized centers can offer integrated treatments for mental health, substance use disorders, and the symptoms that accompany both.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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