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There is not enough evidence to know if Rexulti (brexpiprazole) is harmful to a developing fetus. However, pregnant parents who take antipsychotic drugs like Rexulti during the third trimester seem to place their fetus at greater risk for muscle movement problems and withdrawal symptoms.

If you become pregnant while taking this drug, talk to your doctor about registering with the National Pregnancy Registry for Atypical Antipsychotics.

Rexulti and Lactation

There are no lactation studies on humans that assess the presence of Rexulti in breastmilk, the effects of this drug on the breastfed infant, or the effects of this drug on the production of breastmilk. However, experts have found this medication in rat milk, which suggests it is possible for it to appear in human milk, too. 


Is Rexulti safe while pregnant?

There is not enough evidence to determine whether Rexulti is safe during pregnancy. But experts have observed that, when taken during the third trimester of pregnancy, antipsychotic drugs like this one can increase the risk for muscle movement problems and withdrawal symptoms in the fetus.

How long does Rexulti take to work?

Rexulti’s effect may vary from patient to patient as not everyone responds to this medication the same way. Keep your doctor updated on how you are feeling, including any side effects, so that they can better understand what effect the treatment is having on you and adjust it if necessary.

That being said, it can take a week or two for some symptoms to start improving. Although, it may take up to 3 months before you start to feel the full effects of brexpiprazole.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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