Dangerous oxycodone and alcohol interactions can occur. Even a small amount of alcohol can have an impact.
The most dangerous side effect of mixing oxycodone and alcohol is the risk of overdose. Both oxycodone and alcohol can depress the respiratory system, as well. They both affect a person’s judgment and decision-making, putting them in further risk. It affects their ability to judge how much alcohol they drink, too, so they can become dangerously intoxicated.
Both alcohol and oxycodone depress the respiratory system and affect judgment potentially leading to profound sedation, respiratory depression/distress, coma, and even death.