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Amoxicillin is currently the 18th most commonly prescribed drug in the United States. In 2017 alone, there were almost 28 million prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long Amoxicillin stays in your system. 

The FDA states the following information regarding amoxicillin’s half-life: 

Mean effective half-life: 61.3 minutes

Time to steady-state: Three days

Terminal phase half-life: 1.27 hours 

Amoxicillin has an oral bioavailability of 77.4%. The drug readily diffuses into most body tissues and fluids, but not brain and spinal fluid. 


What is the half-life of amoxicillin? 

The half-life of amoxicillin is 61.3 minutes. 

How long does amoxicillin stay in your system?

Amoxicillin is likely detectable in your system for the following time frames:

(Numbers above are merely estimates, and may vary based on several factors, such as age and other medical conditions.)

How long does it take for antibiotics to get out of your system? 

Within six to eight hours, 60% of an orally administered dose of amoxicillin is excreted through the urine.

How is amoxicillin metabolized? 

Amoxicillin is metabolized by the liver.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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