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As is the case with any other medication, there may be some instances where amoxicillin use is not recommended or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions 

According to the U.S. National Library of Medicine, drugs that may interact with amoxicillin include the following. 

  • Probenecid
  • Oral Anticoagulants
  • Allopurinol
  • Oral Contraceptives
  • Other Antibacterials

Please note that this list may not be complete, and other interactions with drugs not listed here may occur. 

Amoxicillin and Clavulanate Potassium 

Clavulanate potassium is commonly used in collaboration with amoxicillin. Specifically, this beta-lactamase inhibitor is regularly used to help prevent certain bacteria from becoming resistant to amoxicillin. This combination is called Augmentin, and is sometimes used to treat different infections than amoxicillin.

Amoxicillin and Tums 

Taking an antacid like Tums should NOT lower the effectiveness of amoxicillin.

Amoxicillin and Penicillin 

Amoxicillin and penicillin are in the same family of drugs and have similar interactions to other medicines. 

Amoxicillin and Tylenol 

There are no known interactions between amoxicillin and Tylenol (acetaminophen). Patients, however, should still clear Tylenol use with their prescribing physician before taking it with an antibiotic.

Food Interactions 

Sometimes the foods we eat and the beverages we drink can also interact with our medications. 

Food and drink that may interact with amoxicillin include: 

  • Any dairy products
  • Alcohol
  • Acidic food and drink like orange juice and tomatoes. 
  • Whole grains and other foods with a high amount of fiber. 

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug. 

Amoxicillin and Milk 

Consuming any dairy products, including milk, can cause diarrhea, a potential side effect of amoxicillin. Mixing dairy and amoxicillin can increase the chances of this. 

Amoxicillin and Beer 

Alcohol of any kind, including beer, can lead to negative side effects if on amoxicillin. While it will not interfere with the benefits of the medicine, it can lead to gastrointestinal issues such as vomiting, nausea, diarrhea, and dizziness. 

Amoxicillin and Alcohol

For more information, please refer to our page on amoxicillin and alcohol interactions.

Condition & Disease Interactions 

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. 

According to the U.S. National Library of Medicine, diseases and medical conditions that are known to negatively interact with amoxicillin include: 

  • Kidney Disease
  • Mono
  • Allergies
  • Asthma
  • Hay fever
  • Hives
  • Phenylketonuria

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take amoxicillin. 

Amoxicillin and Pregnancy

For more information, please refer to our page on amoxicillin and pregnancy interactions.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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