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Otezla (apremilast) is a popular prescription medication used to treat psoriasis and psoriatic arthritis. As such, it pays to know a little bit more about this medication, including how long Otezla stays in your system.

Experts the following information regarding Otzela (apremilast) half-life:

Terminal elimination half-life: 6 to 9 hours

Mean terminal half-life at steady-state: 6 to 8 hours

Time to stead-state: 36 hours in healthy adults with twice-daily dosing

Peak plasma concentration: about 2.5 hours after an oral dose

Accumulation ratio: About 1.7

What is the half-life of Otezla?

The FDA states the half-life of Otezla is approximately 6 to 9 hours.

How long does Otezla stay in your system?

Given its half-life of 6 to 9 hours, it’s likely that it could take the body anywhere from 33 hours to 49.5 hours to clear apremilast.

What happens when you stop taking Otezla?

There are no withdrawal effects of stopping Otezla, but it is still important to consult with your doctor before stopping treatment with Otezla. With most prescription medications, it is not recommended to abruptly stop medication, as old symptoms could return or withdrawal symptoms could surface.

For more information on stopping treatment with Otezla, visit our withdrawal page.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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