OverviewDosageSide EffectsInteractionsHalf-Life

Oxycodone was the 52nd  most commonly prescribed drug in the United States in 2017. In that year alone, there were over 15 million prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long oxycodone stays in your system.

How long does oxycodone stay in your system?

Oxycodone is detectable in your system for the following time frames:

– Your blood for 24 hours

– Your saliva for 4 days

– Your urine for 1 to 4 days

– Your hair for 90 days

Oxycodone Half-Life

The FDA states the following information regarding oxycodone half-life:

Mean effective half-life:  4.5 hours for extended-release tablets and 3.2 hours for immediate-release tablets

Time to steady-state: 24 to 36 hours

 Mean accumulation ratio: N/A

Terminal phase half-life: 4.5 hours 

Oxycodone has an oral bioavailability of 60 to 87 percent, which is an indication that the body readily absorbs this drug. Excretion is via the kidneys. 


How long does it take for oxycodone to work?

Most people feel relief with oxycodone within 40 minutes.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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