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Trazodone is an antidepressant typically prescribed to treat anxiety, depression, and sometimes sleep problems.

What is the half-life of trazodone?

The FDA reports that peak plasma levels of trazodone occur around one hour after dosing when a person takes the medication on an empty stomach and around two hours when the person takes the medication with food.

The plasma elimination half-life of trazodone differs from older people (13.6 hours) to younger people (6 hours) in the “fasted state,” though, according to PubChem. PubChem also reports that trazodone half-life ranges from around 3 to 6 hours, and then 5 to 9 hours in a second terminal phase.

Is it ok to take 100mg of trazodone for sleep?

For specific dosage information, you should consult with your doctor. Taking trazodone for sleep-related problems is not for everyone.

For more information about dosage, visit our trazodone dosage page.

For more information about taking this medication for sleep, visit our trazodone for sleep page.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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