TrazodoneDosageSide EffectsInteractionsHalf-Life

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Generic Names: trazodone
Brand Names: Desyrel
Drug Class: selective serotonin reuptake inhibitors (SSRIs); serotonin antagonist and reuptake inhibitors (SARIs), antidepressant , (also may block histamine and alpha 1 adrenergic receptors)
Availability: Prescription needed
Molecular Formula: C19H22HIN5O
UNII: YBK48BXK30

What is trazodone?

Trazodone is a type of antidepressant.

What is trazodone used for?

Trazodone is prescribed to treat various psychological problems and disorders, including but not limited to: depression, anxiety, major depressive disorder (MDD), schizoaffective disorders, and insomnia. It requires a prescription.

How does trazodone work?

Trazodone changes the way the neurotransmitters-such as dopamine and serotonin-in your brain communicate. Trazodone inhibits, or blocks, the reuptake of serotonin. Also, trazodone may block histamine and adrenergic receptors in conjunction with reuptake of serotonin.

How long does it take for trazodone to work?

As with many antidepressant medications for best results it may take up to 6 weeks for full effect, which is why it is important to take this medication exactly as prescribed.

For more information regarding the half-life of trazodone, visit our half-life page.

Do not use trazodone if:

Trazodone may not be for everyone. In order to determine whether or not this medication is right for you, talk with your physician. The FDA outlines specific instances in which trazodone should be avoided or prescribed/taken with extra caution. Some of these cases include:

  • People with bipolar disorder
  • People who have had a heart attack, heart problems, or a family history of heart health problems
  • People with liver and/or kidney problems
  • People who are breastfeeding, pregnant, planning to become pregnant, or believe they might be pregnant
  • People with other serious medical conditions or health problems
  • People taking other medications (some exceptions may apply), including but not limited to: lithium, other SNRIs or SSRIs, warfarin, aspirin, diuretics, nonsteroidal anti-inflammatory drugs (NSAIDs), monamine oxidase inhibitors (MAOI’s) ((within 14 days of use of a MAOI)), linezolid, and methylene blue.

Please note that this list may not include all potential cases in which someone should avoid using trazodone. Always consult with your physician about the potential risks and side effects of taking this medication.

For more information on trazodone interactions, visit our interactions page.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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