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As is the case with any other medication, there may be some instances where mupirocin interactions can occur. In such cases, use is not recommended, or usage will have to be adjusted to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with mupirocin include the following.

  • There are no known drug interactions for this medication.

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Mupirocin and Hydrocortisone

There is an indication that these two medications could work together to combat certain infections but no sign of negative interactions.

Mupirocin and Bactrim

There are no known interactions between mupirocin and Bactrim, an oral or IV antibiotic.

Mupirocin and Triamcinolone

Triamcinolone is a topical corticosteroid. There are no known interactions between these two drugs.

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with mupirocin include:

  • There are no specific food interactions for mupirocin

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Mupirocin and Alcohol

For more information, please visit our page on mupirocin and alcohol interactions.

Disease & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases, and medical conditions that are known to negatively interact with mupirocin include:

  • Mupirocin should not be used near sites of an intravenous cannula (IV) or central intravenous (central line)
  • It should not be used where there is a risk of a large amount of polyethylene glycol absorption (an ingredient in the ointment), especially in those with renal conditions; that would include mucosal surfaces

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Mupirocin and MRSA

Mupirocin may be effective to decolonize MRSA in carriers without symptoms and for soft tissue and skin MRSA infections

Mupirocin and Ringworm

Ringworm is a fungal skin infection, and mupirocin is for the treatment of bacterial infections. Some animal studies have shown that mupirocin might have some antifungal properties, but it is not the best choice to treat ringworm. 

Mupirocin and Acne

Mupirocin is not a common treatment for cystic acne. 

Mupirocin and Sulfa Allergy

Those with a sulfa allergy should be able to use mupirocin with a medical provider’s approval. 

Mupirocin and Boils

Mupirocin is often used in the treatment of boils, which occur when a hair follicle becomes infected with bacteria. 

Mupirocin and Pregnancy

For more information, please visit our page on Mupirocin and pregnancy risks.

Other Interactions

Other potential interactions include the following.

Mupirocin and Poison Ivy

Mupirocin is not a typical treatment for poison ivy (contact dermatitis). If the area becomes infected, though, a physician might consider a topical antibiotic like mupirocin. 

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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