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As is the case with any other medication, there may be some instances where Percocet interactions can occur. In such cases, use is not recommended, or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with Percocet include the following.

  • Skeletal muscle relaxants, such as carisoprodol (Soma), cyclobenzaprine (Flexeril), and metaxalone (Skelaxin)
  • CNS depressants like diazepam (Valium)
  • Agonist/antagonist analgesics like Pentazocine (Talwin), Nalbuphine (Nubain), Naltrexone (ReVia), and Butorphanol (Stadol)
  • Alcohol
  • Anticholinergics like atropine (Atropen)
  • Loop diuretics like bumetanide (Bumex)
  • Probenecid (Probalan)
  • Zidovudine (Retrovir)

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Xanax

Alprazolam (Xanax) is a benzodiazepine (“benzo”) used to treat anxiety disorders. Like Percocet, it works by inhibiting certain actions in the central nervous system. In general, it is a bad idea to mix opioid pain medications like Percocet with any drug that acts on the central nervous system. The combination may severely depress breathing, leading to coma or even death. 

Ibuprofen

Although experts have noted no specific interactions between Percocet and ibuprofen (Advil), there may be no benefit in mixing them. 

Tylenol (Acetaminophen)

Tylenol is the trade name of acetaminophen, one of the main components in Percocet. Mixing the two medications could lead to an overdose of acetaminophen, which can damage the liver.

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with Percocet include:

  • Grapefruit and grapefruit juice
  • Alcohol

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Percocet and Alcohol

For more information, please visit our page on Percocet and alcohol interactions.

Disease & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases, and medical conditions that are known to negatively interact with Percocet include:

  • Severe bronchitis
  • Uncontrolled asthma
  • Any conditions that depresses breathing
  • Chronic alcoholism
  • Head injury
  • Increase intracranial pressure
  • Liver disease
  • COPD
  • Seizures
  • Thyroid dysfunction
  • Adrenal insufficiency
  • Kidney impairment

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Percocet and Breastfeeding

For more information, please visit our page on Percocet and pregnancy risks.

Percocet and Pregnancy

For more information, please visit our page on Percocet and breastfeeding risks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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