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Percocet and alcohol interactions can occur.

Side Effects

Percocet and alcohol both depress the central nervous system (CNS), which plays a part in key bodily functions. This fact means taking them together might lead to severe respiratory depression. It may also enhance other sedation side effects of both drugs. 

Interaction

Alcohol and the oxycodone in Percocet both depress the CNS. The most serious potential interaction is respiratory depression, or hypoventilation. This condition means someone is breathing slowly and ineffectively, which can lead to problems like oxygen deprivation. In severe cases, breathing may even stop.

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