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Percocet and pregnancy studies have not been conducted in animals. That said, nonhuman animal studies of opioid use during pregnancy show adverse effects on the fetus. In fact, clinical studies indicate that taking opioids early in pregnancy doubles a woman’s chance of giving birth to a baby with neural tube defects like spina bifida.  

Percocet and Breastfeeding

Nursing mothers should not take Percocet because it may depress breathing in the infant. The opioid in this drug (oxycodone) is excreted in breast milk. 


What happens if you take oxycodone while pregnant?

A woman who takes oxycodone during pregnancy should only do so with medical supervision and only when absolutely necessary. A baby born to a mother who takes opioids like oxycodone may become addicted and go through withdrawal after birth. Taking an opioid can also increase the risk of birth defects when taken early in the pregnancy. 

Is it safe to take opioids while pregnant?

Women should always follow the advice of their physician when it comes to taking any medication during pregnancy. Opioids are highly addictive, and many babies born to women who take them either therapeutically or recreationally are born with an addiction and go through withdrawal after birth. 

There is also an indication that women who take opioids during pregnancy may increase the risk of birth defects, such as cleft palate, gastroschisis, or spina bifida. 

What pregnancy category is Percocet?

Percocet is listed in pregnancy category C

Which painkiller is safe during pregnancy?

Women should follow the advice of physicians for pain management during their pregnancy. Acetaminophen is usually allowed during pregnancy. Ideally, women should try alternative pain relief options, too, like ice to reduce inflammation. 

Expecting mothers should avoid aspirin and other NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen (Advil). 

Can Percocet cause birth defects?

Opioids may as much as double the odds of birth defects. In general, expectant parents should avoid opioids and NSAIDs. 

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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