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Percocet may not be the right choice for every patient. In such cases, it is important to discuss with a medical provider potential Percocet alternatives.

Alternatives for Percocet — What Are Your Options?

What are your options when it comes to alternatives for Percocet?


Like Percocet, Vicodin is an opioid drug that combines two medications, hydrocodone and acetaminophen (Tylenol, acetaminophen). For someone with a sensitivity to oxycodone, Vicodin might be a practical alternative. It works as a central nervous system depressant, just like Percocet, and utilizes the analgesic (painkiller) acetaminophen. As such, it may be able to relieve pain similarly to Percocet without triggering an allergic reaction.

Amoxapine (Asendin)

Amoxapine and other tricyclic antidepressants (TCAs) have proven effective in the management of chronic pain, especially neuropathic pain or conditions like fibromyalgia. It’s not clear why these medications have an analgesic, or painkilling, effect, though. 

Diazepam (Valium)

Some benzodiazepines (“benzos”) like Valium can help relax muscles to relieve pain, as well. Like opioids, though, benzodiazepines are potentially addictive

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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