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As is the case with any other medication, there may be some instances where Vyvanse interactions can occur. In such cases, use is not recommended, or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.

Drug Interactions

According to the FDA, drugs that may interact with Vyvanse include the following.

  • Monoamines oxidase inhibitors (MAOs)
  • Acidifying and alkalinizing agents 
  • Quinolones
  • Opioid Agonists
  • SSRI medications
  • Others not on this page or listed below

Please note that this list may not be complete, and other interactions with drugs not listed here may occur.

Wellbutrin

Wellbutrin (bupropion) is a drug used to treat depression and both of these drugs may cause seizures. Combining them might increase that risk. 

Antihistamine

Vyvanse is an amphetamine. Combining it with antihistamines may enhance certain side effects like jitteriness. It may also increase blood pressure and heart rate. 

CBD (cannabinoid)

Vyvanse is a prodrug, meaning it relies on enzymes to activate it. CBD inhibits some enzymes, so taking it with Vyvanse may keep the drug from activating. 

Lexapro

Lexapro (escitalopram) is a selective serotonin reuptake inhibitor (SSRI). Taking SSRIs with Vyvanse may increase the risk of a rare condition called serotonin syndrome, which can cause death. 

Ibuprofen

Both ibuprofen (Advil) and Vyvanse can elevate blood pressure. Taking them together may increase blood pressure. 

Mirtazapine

Remeron (mirtazapine) is an antidepressant and Vyvanse is a stimulant. Taking them together may enhance certain side effects. Alternatively, they may also cancel out each other’s effects. For example, Remeron is sometimes used to promote sleep, while Vyvanse has the opposite effect. Taking both together could therefore cause no change in energy levels.

Adderall

Adderall and Vyvanse are both amphetamines. Combining amphetamines will amplify the effects and may lead to dangerous complications.

Prozac

Prozac (fluoxetine) is a selective serotonin reuptake inhibitor (SSRI). Taking SSRIs with Vyvanse can increase the risk of a rare but dangerous side effect called serotonin syndrome

Zoloft

Zoloft (sertraline) is a selective serotonin reuptake inhibitor (SSRI). Taking SSRIs with Vyvanse can increase the risk of a rare but dangerous side effect called serotonin syndrome

Food Interactions

Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with Vyvanse include:

  • Caffeine
  • Foods high in vitamin C

Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.

Vyvanse and Alcohol

For more information, please visit our page on Vyvanse and alcohol interactions.

Vitamins

Certain vitamins increase the acidity of the blood, which may decrease the effectiveness of Vyvanse. As such, patients should avoid vitamin C supplements while taking this drug. 

Food

Vitamin C in foods may have the same effect as supplements; that is, they may decrease how effective Vyvanse is. Patients therefore should limit their intake of foods high in vitamin C, such as citrus fruits, broccoli, and cauliflower. (regular daily portions of these foods is fine)

Caffeine

Caffeine–found in soda, coffee, tea, and chocolate–is a stimulant. When combined with an amphetamine like Vyvanse, they can increase the stimulant effects of both. 

Disease & Conditions Interactions

Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases, and medical conditions that are known to negatively interact with Vyvanse include:

  • None listed

Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.

Vyvanse and Breastfeeding

For more information, please visit our page on Vyvanse and pregnancy risks.

Vyvanse and Pregnancy

For more information, please visit our page on Vyvanse and pregnancy risks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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