How Long Does It Take For Probiotics To Work?

The three-strain probiotic formula Floradapt Intensive GI, marketed by Kaneka Probiotics, was found to improve stomach and mood symptoms in a population of healthy subjects experiencing symptoms similar to irritable bowel syndrome (IBS), a condition often associated with stress, depression, and anxiety.

This study aimed to test whether probiotic blends (KABP-021, KABP-022, and KABP-023) improved diarrhea-related problems in healthy adults.

It is often the case that healthy individuals with abdominal symptoms do not receive optimal medical treatment and therapies because they are considered healthy. However, patients with irritable bowel syndrome (IBS) can receive appropriate treatment under the supervision of a doctor. 

Many healthy individuals suffer from the sensitive inconveniences of defecation and reduced quality of life (QOL). They cannot find any other way to treat themselves than by using over-the-counter drugs, traditional therapies, or specific diets based on their assessment. 

Despite these efforts, some of their symptoms may temporarily subside; therefore, the healthcare industry must implement more sustainable solutions early. There are approximately 4% of individuals worldwide with IBS, one of the most prevalent functional gastrointestinal disorders (recently renamed gut-brain axis disorders), and many more suffer from IBS undiagnosed.

In the study, researchers recruited a healthy group of volunteers based on the following inclusion criteria: Females and males between the ages of 20 and 65 regularly experience stress and diarrhea with abdominal pain and discomfort. The volunteers received either a daily dose of probiotics or a placebo.

A physician assessed the participants and determined not to have functional gastrointestinal disorders (gut-brain axis disorders), such as inflammatory bowel disease (IBD) and IBS.

The researchers gave a probiotic product containing three strains of lactic acid bacteria in a capsule: Pediococcus acidilactici KABP-021 (CECT7483), Lactiplantibacillus Plantarum KABP-022 (CECT7484), and L. Plantarum.

Results Of The Study

As measured by a test called the Izumo scale, participants receiving the probiotic formula reported significantly lower levels of stress-related diarrhea and total diarrhea following the month-long intervention. In addition, these participants reported improved mental health and well-being during the study, as indicated by improved scores on the SF-8 questionnaire, which measures health-related quality of life (QOL).

According to the researchers, the formulation reduces intestinal permeability and inflammation with positive GI effects. This is done by generating metabolites, such as polyphosphates, acetylcholine, or acetate, which counter stress’ damaging effects on the intestinal mucosa.

It has also been shown that increased numbers of butyric acid-producing Faecalibacterium prausnitzii correlate with improved diarrhea scores for subjects receiving probiotics but not placebos. Acetic acid, one of the substances produced by probiotic formulations, stimulates Faecalibacterium.

 As a result of the probiotic intervention, researchers proposed that intestinal permeability had been decreased and gut microbiota had been modulated, supporting beneficial bacteria like Faecalibacterium, and normalizing the gut-brain axis.

Therefore, a specific blend of probiotics supplemented for four weeks reduced diarrhea-related symptoms and may enhance mental health and daily activities among healthy individuals under stressful circumstances.

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