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Below are the general guidelines for dosing baclofen. Note that these dosages may be adjusted on a case-by-case basis for individual patients. Always follow your prescribing physician’s instructions for taking baclofen.

The following information comes from DailyMed, an FDA label information provider.

What if I miss a dose of baclofen?

According to Mayo Clinic, if you miss a dose of baclofen, take the missed dose immediately, unless you are closer in time to your next available dose. Never double doses.

What if I overdose on baclofen?

**If you believe you or someone you know has overdosed, call 911 immediately for medical assistance.

Signs and Symptoms: Vomiting, muscular hypotonia, drowsiness, accommodation disorders, coma, respiratory depression and seizures.

Treatment: In the alert patient, empty the stomach promptly by induced emesis followed by lavage. In the obtunded patient, secure the airway with a cuffed endotracheal tube before beginning lavage (do not induce emesis). Maintain adequate respiratory exchange, do not use respiratory stimulants.

Dosage and Administration

The determination of optimal dosage requires individual titration. Start therapy at a low dosage and increase gradually until optimum effect is achieved (usually between 15-80 mg daily spread throughout the day.) Some patients are placed on a intrathecal baclofen pump that delivers doses that way.

The following dosage titration schedule is suggested:

                                                            5 mg t.i.d. for 3 days

                                                            10 mg t.i.d. for 3 days

                                                            15 mg t.i.d. for 3 days

                                                            20 mg t.i.d. for 3 days

Thereafter additional increases may be necessary but the total dose should not exceed a maximum of 80 mg daily (20 mg q.i.d).

The lowest dose compatible with an optimal response is recommended. If benefits are not evident after a reasonable trial period, patients should be slowly withdrawn from the drug (see WARNINGS ABRUPT DRUG WITHDRAWAL).

How is baclofen supplied?

Baclofen Tablets, USP, 10 mg are white to off white, round, flat face bevel edge, uncoated tablets debossed ‘291’ on one side and scored on other side are available as follows:

Bottles of 100                        NDC 57664-291-88
Bottles of 500                        NDC 57664-291-13
Bottles of 1000                       NDC 57664-291-18

Baclofen Tablets, USP, 20 mg are white to off white, round, flat face bevel edge, uncoated tablets debossed ‘292’ on one side and scored on other side are available as follows:

Bottles of 100                         NDC 57664-292-88
Bottles of 500                         NDC 57664-292-13
Bottles of 1000                      NDC 57664-292-18

PHARMACIST: Dispense in well closed container with child resistant closure as defined in USP.

Store at 20 – 25° C (68 – 77° F) [See USP Controlled Room Temperature].

C.S. No.: 5532T01

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.


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