OverviewDosageSide EffectsInteractionsHalf-Life

Recent studies show that Entyvio (vedolizumab) offers an effective option for controlling moderate to severe ulcerative colitis and Crohn’s disease. As such, this medication is being prescribed more often, especially for those who normally rely on corticosteroids. Considering how popular this medication is becoming, it’s important to learn more about it, including how long Entyvio stays in your system.

Clinical studies found the following information regarding vedolizumab half-life:

Mean effective half-life: 25 days at 300 mg

Time to steady-state: 46 weeks

Terminal phase half-life: 25.5 days

Entyvio is administered as a subcutaneous injection and is readily absorbed. It leaves your body through linear and non-linear methods, including being broken down to peptides and amino acids. These are either reused in your body or excreted by your kidneys.


What is the half-life of Entyvio?

Clinical studies show that the half-life of Entyvio is roughly 25 days when given at 300 mg dosages. The terminal phase half-life is roughly 25.5 days.

How long does Entyvio stay in your system?

Entyvio has a linear clearance rate of 0.157 L/day based on clinical studies. This medication was not found in samples of cerebrospinal fluid at 5 weeks after patients received a single injection of 450 mg, which is 1.5 times the recommended dosage.

Information on drug test detection windows for Entyvio is unavailable. Keep in mind that different types of drug tests are used for detecting medications and other substances.

  • Urine test: These tests are done to detect traces of alcohol, opioids, and other substances in urine. Detection windows for urine tests vary based on substance types, body mass, and other factors. These windows have a range of several hours to one month.
  • Blood/plasma/serum test: These drug tests check plasma, serum, or blood samples for traces of cocaine, opiates, and other substances. These types of drug tests have shorter detection windows, with some being just a few hours. The type of substance affects the detection window.
  • Hair test: This type of drug test examines samples of hair follicles for traces of amphetamines, opiates, and other substances. Hair tests can have detection windows of 90 days or less.

How long does it take for vedolizumab to work?

The length of time it takes for vedolizumab to work varies for each patient. While it’s possible to begin experiencing some relief from symptoms of ulcerative colitis or Crohn’s disease after the initial injection, clinical studies show that it took roughly 4 to 6 weeks for this to occur in patients with ulcerative colitis who received 300 mg dosages. Vedolizumab injections are typically given at 1, 2, and 6 weeks, followed by injections given every 8 weeks.

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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