OverviewDosageSide EffectsInteractionsHalf-Life

Vyvanse was the 91st most commonly prescribed drug in the United States in 2017. In that year alone, there were over 8.8 million prescriptions. Considering how popular this drug is right now, it pays to know a little bit more about this medication, including how long Vyvanse stays in your system.

Basic Information

Mean effective half-life: 12 hours

Mean accumulation ratio: 0 – No accumulation of lisdexamfetamine and dextroamphetamine

Terminal phase half-life: 12 hours

Vyvanse has an oral bioavailability of 96 percent. Once digested, lisdexamfetamine becomes 100 percent dextroamphetamine. It is excreted via urine. 


What is the half-life of Vyvanse?

12 hours.

How long does Vyvanse stay in your system?

Vyvanse is detectable in your system for the following time frames:

  • Your blood for up to eight hours.
  • Your saliva for NA.
  • Your urine for three days or longer.
  • Your hair for NA

Since this drug has a half-life of 12 hours, it can stay in the body for up to three days

How long does Vyvanse last in a day?

One dose may last up to 14 hours. 

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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