As is the case with any other medication, there may be some instances where Jardiance (empagliflozin) interactions can occur. In such cases, use is not recommended or usage will have to be adjusted in order to prevent or reduce the risk of negative interactions occurring from other drugs, medical conditions, or even food and drink.
NOTE: Do not stop taking medications even if they are on this list. Always discuss your concerns with your physician before stopping a medication.
According to the FDA, drugs that may interact with Jardiance (empagliflozin) include the following:
- Amlodipine (Norvasc)
- Metoprolol (Toprol XL, Lopressor)
- Glipizide (Glucotrol XL, Glucotrol)
- Metformin (Glucophage, Riomet, Glumetza)
- Januvia (sitagliptin)
- Lisinopril (Qbrelis, Zestril, Prinivil)
- Linagliptin (Tradjenta)
- Liraglutide (Victoza 3-Pak, Victoza 2-Pak, Saxenda)
- Furosemide (Lasix)
Please note that this list may not be complete, and other interactions with drugs not listed here may occur.
Amlodipine is used to treat high blood pressure (hypertension) and heart-related chest pain (angina). Because Jardiance may lead to salt and water loss, people who take amlodipine and Jardiance may be at increased risk of low blood pressure (hypotension) and dehydration.
Metoprolol is another medication used to treat high blood pressure and may increase a person’s risk of low blood pressure and dehydration when taken with Jardiance.
Insulin and Jardiance are both used to help treat type 2 diabetes by lowering blood sugar. Since they both lower blood sugar, these drugs may increase a person’s risk of a condition known as hypoglycemia (low blood sugar).
Glipizide is a drug used to treat type 2 diabetes by stimulating the pancreas to produce insulin, a hormone that helps take sugar out of the blood. Taking glipizide and Jardiance together may increase the risk of hypoglycemia (low blood sugar).
No interactions between metformin and Jardiance have been reported. That said, the FDA and other organizations recommend that you always consult with your healthcare provider before adding or changing any medications.
Januvia (sitagliptin) is also used to treat type 2 diabetes. There are no known interactions between Januvia and Jardiance, although patients should still discuss this possibility with a licensed healthcare professional.
Lisinopril is a medication used to treat high blood pressure and heart failure. People who take lisinopril and Jardiance may be at increased risk of low blood pressure and dehydration, because Jardiance may lead to salt and water loss.
Linagliptin (Tradjenta) is another drug used to treat type 2 diabetes. No interactions between linagliptin and Jardiance have been reported. This doesn’t mean interactions aren’t possible.
Liraglutide (Victoza) is used to treat type 2 diabetes and may help promote weight loss in some people. No interactions have been found between liraglutide and Jardiance, although patients should still discuss potential interactions with their prescribing medical provider.
Furosemide (Lasix) is a diuretic used to treat edema and fluid retention. Jardiance may enhance the diuretic effect of furosemide and therefore may increase a person’s risk of dehydration, kidney problems, and low blood pressure.
Sometimes the foods we eat and the beverages we drink can also interact with our medications. Food and drink that may interact with Jardiance include:
Please note that this list may not be complete, and there may be other foods and beverages that interact with this drug.
Jardiance and Alcohol
For more information, please visit our page on Jardiance and alcohol interactions.
Both Jardiance and caffeine (a stimulant found in coffee, certain soft drinks, and chocolate) can increase urination. Consuming foods and beverages that contain caffeine while taking Jardiance may increase the risk of dehydration and low blood pressure.
There are no known interactions between Jardiance and milk. That said, due to its carbohydrate content, milk may lead to high blood sugar in people with type 2 diabetes.
Disease & Conditions Interactions
Sometimes certain medications can increase the risk of negative side effects for patients with certain diseases or other medical conditions. According to the FDA, diseases and medical conditions that are known to negatively interact with Jardiance include:
- Yeast infections
- Pancreatitis (inflammation of the pancreas)
- CKD (chronic kidney disease)
- Hypoglycemia (low blood sugar)
- Pregnancy and lactation
Please note that this list may not be complete, and there may be other diseases and medical conditions where patients should not take this medication.
Urinary tract infections, genital candidiasis, genitourinary infection, vaginal infections, and yeast infections are commonly reported side effects of Jardiance. People who have a history of frequent yeast infections may be at greater risk of serious infections while taking Jardiance.
Pancreatitis (Inflammation of the Pancreas)
The pancreas is an organ that produces insulin, a hormone involved in blood sugar control. Some research links the use of SGLT2 inhibitors like Jardiance with an increased risk of acute pancreatitis, or inflammation of the pancreas. However, more research is needed to clarify the link.
CKD (Chronic Kidney Disease)
The kidneys are major excretory organs in the body and help remove waste and fluids via urine. People with severe kidney disease should not use Jardiance. According to the FDA, Jardiance may lead to acute kidney injury in some cases.
Research indicates that Jardiance may help some people with type 2 diabetes lose weight. However, Jardiance is not approved as a drug specifically to promote weight loss and should not be used solely with this purpose in mind.
Hypoglycemia (Low Blood Sugar)
Hypoglycemia is a condition in which a person’s blood sugar level becomes too low. Hypoglycemia symptoms include
- perspiration, and
- a fast heartbeat (tachycardia).
Jardiance lowers blood sugar and may cause a person’s blood sugar to drop too low in certain situations, especially if taken with other drugs used to treat type 2 diabetes. Jardiance appears to be less likely to cause low blood sugar than other anti-diabetes medications, though.
Jardiance and Pregnancy
For more information, please visit our page on Jardiance and pregnancy risks.
Empagliflozin and Breastfeeding
For more information, please visit our page on Jardiance and pregnancy risks.
Generic Name: Empagliflozin
Class: Sodium-glucose cotransporter 2 (SGLT2) inhibitors
Availability: Prescription only (currently in the United States, no generic version is available)
Molecular Formula: C23H27ClO7
Substance UNII: HDC1R2M35U
What is Jardiance?
Jardiance is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is the brand name of the drug empagliflozin.
What is Jardiance Used For?
Jardiance is used for the treatment of diabetes. It was approved by the U.S. Food and Drug Administration (FDA) in 2014.
According to the U.S. National Library of Medicine, Jardiance can also help lower the risk of heart attack, stroke, and death in people with type 2 diabetes who also have heart and blood vessel diseases.
How Does Jardiance Work?
Jardiance helps lower blood sugar in people with type 2 diabetes. It’s meant to be used along with diet and exercise. It works by helping the kidneys send excess sugar out of the body through the urine.
How Long Does it Take for Jardiance to Work?
Jardiance may start to help lower blood sugar levels within 1 to 2 weeks. But studies suggest it may take up to 24 weeks for a person to get the full benefits of Jardiance.
Do Not Use Jardiance If:
There are several situations where this medication may not be the right choice for you. According to the FDA, the following should not use Jardiance:
- People with type 1 diabetes
- People with allergies or sensitivities to ingredients in Jardiance
- People with severe or end-stage kidney disease, including people who are on dialysis
- People with diabetic ketoacidosis (a serious health condition that can occur if high blood sugar is left untreated)
Please note that this list may not be complete, and there may be other situations where the use of this drug is not advisable.