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Metformin for PCOS (polycystic ovary syndrome) is a common approach to increasing a woman’s chance of giving birth. It may restore menstrual cycles and increase the chances of live birth. 

How Does Metformin for PCOS Work?

Metformin for PCOS works the same way as it does for diabetes. There is evidence that insulin sensitivity may play a role in PCOS. Metformin makes cells less sensitive to the hormone, increasing a woman’s chance of ovulation and a regular menstrual cycle. 


  • 500 mg once a day for the first one to two weeks
  • 500 mg twice a day for the next one to two weeks
  • 500 mg three times or 850 mg twice a day for one for two weeks
  • 1g twice a day or 850 mg three times a day thereafter

Titration/increase in dosage is based on presence and/or tolerance to side effects.

Side Effects

  • Nausea
  • Abdominal bloating
  • Gas
  • Vomiting
  • Diarrhea
  • Headache
  • Dizziness

Disclaimer: this article does not constitute or replace medical advice. If you have an emergency or a serious medical question, please contact a medical professional or call 911 immediately. To see our full medical disclaimer, visit our Terms of Use page.

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